The annotation rating supplies a measure that is heuristic of annotation content of the UniProtKB entry or proteome
This score can’t be utilized being a measure of the accuracy associated with the annotation even as we cannot define the ‘correct annotation’ for almost any offered protein.
– Experimental evidence at transcript level i
This means that the type of pr f that supports the protein. Observe that the ‘protein presence’ evidence will not give home elevators the correctness or accuracy associated with the sequence(s) shown.
Decide on a section in the left to see content.
This section provides any helpful details about the protein, mostly biological knowledge.
Information which includes been created by the UniProtKB automatic annotation system, without handb k validation.
Automated assertion in accordance with rules i
The Gene Ontology (GO) project offers a set of hierarchical controlled vocabulary split up into 3 groups
GO – Molecular function i
- antiporter task Source InterPro
- xenobiotic transmembrane transporter activity Source InterPro
Protein family/group databases
Transport Classification Database
This part provides information regarding the protein and gene name(s) and synonym(s) and about the organism that’s the way to obtain the protein sequence.
Names & Taxonomy i
This subsection of the Names and taxonomy section has an list that is exhaustive of names for the protein, from widely used to obsolete, allowing unambiguous recognition of a protein.
Automatic assertion in accordance with rules i
Automated assertion according to guidelines i
This subsection of the Names and taxonomy section indicates the name(s) of this gene(s) that rule for the protein sequence(s) described into the entry. Four distinct tokens occur ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.
Information which includes been imported from another database using procedures that are automatic.
Automatic assertion inferred from database entries i
This subsection of this true Names and taxonomy section provides info on the name(s) regarding the organism that’s the source of the protein sequence.
Automatic assertion inferred from database entries i
This subsection of the Names and taxonomy section shows the identifier that is unique by the N I to the source system associated with protein. This really is referred to as ‘taxonomic identifier’ or ‘taxid’.
This subsection of the Names and taxonomy section provides the taxonomic classification that is hierarchical associated with supply system. It lists the nodes as they appear top-down within the taxonomic tree, because of the more general grouping detailed first.
This area provides informative data on the location and the topology of this mature protein in the cell.
Subcellular location i
- UniProt annotation
- GO – Cellular component
- essential part of membrane supply UniProtKB-KW
This subsection associated with the ‘Subcellular location’ section defines the degree of the region that is membrane-spanning of protein. It denotes the presence of both alpha-helical transmembrane areas therefore the membrane spanning regions of beta-barrel transmembrane proteins.
UniProtKB Keywords constitute a controlled vocabulary by having a hierarchical structure. Keywords summarise the information of a UniProtKB entry and facilitate the search for proteins of interest.
Keyword phrases – Cellular component i
This section provides info on the expression of the gene at the mRNA or protein level in cells or in cells of multicellular organisms.
Gene phrase databases
ExpressionAtlas, Differential and Baseline Expression
This part provides home elevators sequence similarities along with other proteins and also the s that are domain( contained in a protein.
Family & Domains i
This subsection of the ‘Family and Domains’ area defines an area of great interest that cannot be described in other subsections.
Automated assertion in accordance with sequence analysis https://f.dvipcdn.com/data/dating/m1/photos5/44/6/6665446_7.jpg i
This subsection regarding the ‘Family and domain names’ section provides details about the sequence similarity with other proteins.
Sequence similarities i
Automatic assertion in accordance with guidelines i
Automatic assertion according to rules i
Keywords – Domain i
Automated assertion based on rules i
Identification of Orthologs from Complete Genome Data
Family and domain databases
Built-in resource of protein families, domain names and practical web sites
Pfam protein domain database
TIGRFAMs; a protein family database
This area displays by default the canonical protein series and upon request all isoforms described within the entry. It also includes information pertinent towards the sequence(s), including length and molecular weight. The details is filed in numerous subsections. The subsections that are current their content are listed below
This subsection associated with the Sequence section indicates if the sequence that is canonical by standard in the entry is complete or otherwise not.
Sequence status i Complete.
The checksum is a type of redundancy be sure is calculated through the series. It is helpful for tracking sequence updates.
It should be noted that while, in theory, two different sequences might have the exact same checksum value, the likelih d that this will happen is very low.
However UniProtKB may contain entries with identical sequences in the event of multiple genes (paralogs).
The checksum is computed since the series 64-bit Cyclic Redundancy Check value (CRC64) utilizing the generator polynomial x 64 + x 4 + x 3 + x + 1. The algorithm is described within the ISO 3309 standard.